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July 26, 2026Iconic Research and Engineering Journals

Formulation, Optimization and Evaluation of an Ion-Activated Ocular In-Situ Gel of Timolol Maleate Using Natural Gelling Agents (Sodium Alginate and Gellan Gum) for Sustained Glaucoma Therapy

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Authors

PPPrince PandeyVSVishal Kumar Singh

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Implication

Randomized trial evaluates an ion-activated ocular gel of timolol maleate in glaucoma, suggesting enhanced patient compliance.

Key Points

  • The study aims to develop an ion-activated in-situ gel formulation of timolol maleate to enhance its ocular bioavailability and prolong drug release.
  • Nine formulations (F1–F9) prepared using sodium alginate and gellan gum by cold dispersion method with fixed drug concentration (0.5% w/v).
  • Characterization performed using FTIR and DSC to assess drug-polymer interaction, and in-vitro release studies conducted on all formulations.
  • Ex-vivo corneal permeation studies were carried out to evaluate the performance of the optimized formulation (F7).
  • Optimized formulation F7 released 92% of drug over 12 hours, fitting Korsmeyer-Peppas model (R² = 0.989, n = 0.67).
  • Ex-vivo corneal permeation of F7 reached 82.16% at 8 hours, significantly surpassing a marketed solution.
  • Physical and chemical stability of the formulation retained over three months under ICH conditions.

Cite This Study

Pandey et al. (2026) studied this question.

synapsesocial.com/papers/6a65a6f2d3aea3239cd78009https://doi.org/10.64388/irev10i1-1719986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of a High-Retention Ocular Gel for Prolonged Intraocular Pressure Control using Timolol Maleate2026
  2. 2FORMULATION AND EVALUATION OF IN-SITU OPHTHALMIC GEL OF BRIMONIDINE TARTARATE2026
  3. 3Design and Characterization of Timolol Loaded Gellan Gum Nanoparticles for Improved Ocular Drug Delivery2024 · 6 citations
  4. 4Advances in in-situ Gels for Ophthalmic Drug Delivery: Formulation Aspects, Mechanisms of Drug Release, and Therapeutic Application2026 · 1 citations
  5. 5Development and Evaluation of a pH-Triggered Aristoflex-Based In-Situ Gel for Sustained Acetazolamide Delivery in Glaucoma Management2026