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This research aims to develop multifunctional nanocomposites for enhancing diabetic wound healing by targeting MRSA infections.

February 5, 2026Small ScienceOpen Access

Bimetallic Nanozymes/Polypyrrole/Methylene Blue Platform for Photothermal and Catalytic Biofilm Disruption and Angiogenesis Enhancement in Diabetic Wound Healing

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Demonstrates effective biofilm disruption and angiogenesis in diabetic wounds, suggesting a new therapeutic approach.

This research aims to develop multifunctional nanocomposites for enhancing diabetic wound healing by targeting MRSA infections.
Developed CeZn@PPY@MB nanoflowers with polypyrrole and methylene blue for antibiotic alternatives.
Utilized scanning electron microscopy and X-ray analysis to confirm morphology and composition.
Assessed wound healing through modulation of inflammatory and regeneration markers.
CeZn@PPY@MB nanoflowers showed strong antibacterial effects against MRSA.
Significantly increased collagen deposition and angiogenesis in diabetic wound models.
Demonstrated effective biofilm disruption and rapid wound healing with reduced inflammation.

Kothari et al. (2026) studied this question.

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