Key result
Combining OCT, LVA/echo, and CMR increases MINOCA diagnostic yield to ~62% versus OCT alone.
Why the study?
MINOCA presents a diagnostic and therapeutic dilemma because an overt cause is frequently unidentified, and data were needed on the diagnostic yield of a contemporary protocol combining OCT and CMR beyond coronary angiography.
Does a structured diagnostic protocol including OCT, LVA/echo, and CMR improve the diagnostic yield in patients with MINOCA?
Cohort (n=183)
Yes
Does a structured diagnostic protocol including OCT, LVA/echo, and CMR improve the diagnostic yield in patients with MINOCA?
Absolute Event Rate: 62% vs 20%
A structured diagnostic protocol integrating OCT, LVA/echo, and CMR successfully identifies the underlying cause in 62% of patients with MINOCA.
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May support multimodal imaging protocols in MINOCA; extends observational data but leaves open impact on outcomes.
Nishimiya et al. (2025) conducted a cohort in Myocardial infarction with non-obstructive coronary arteries (MINOCA) (n=183). Structured diagnostic protocol (OCT, LVA/echo, and CMR) vs. OCT alone was evaluated on Diagnostic yield (identification of underlying cause). Combining optical coherence tomography, left ventricular angiography/echo, and cardiac magnetic resonance identified an underlying cause in 62% of MINOCA patients, compared to 20% with OCT alone.
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