Key result
A chronic, closed-chest mouse model allowed for significant IL-6 and TNF-α mRNA induction during myocardial ischemia-reperfusion without interference from acute surgical trauma.
Population
Mouse model of myocardial ischemia-reperfusion
Comparison
Myocardial ischemia-reperfusion using a chronic… vs Acute surgical preparation and naive hearts
Design
Preclinical
Follow-up
Up to 1 week
Authors
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May refine preclinical cytokine studies in myocardial ischemia-reperfusion; leaves open clinical translation.
A chronic, closed-chest mouse model is essential for studying cytokine responses in myocardial ischemia-reperfusion to avoid confounding by acute surgical trauma.
Nossuli et al. (2000) studied this question. A chronic, closed-chest mouse model allowed for significant IL-6 and TNF-α mRNA induction during myocardial ischemia-reperfusion without interference from acute surgical trauma.
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