Why the study?
Does ischemia-reperfusion induce delayed expression of cytokines and contribute to cardiac dysfunction and remodeling in male Wistar rats?
Does ischemia-reperfusion induce delayed expression of cytokines and contribute to cardiac dysfunction and remodeling in male Wistar rats?
Overexpression of proinflammatory cytokines during the first week after ischemia-reperfusion may contribute to early cardiac dysfunction and ventricular remodeling.
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May implicate early cytokine surge in rodent post-IR remodeling; leaves open translational relevance to human therapies.
Moro et al. (2007) studied this question.
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