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February 4, 2026Journal of Immunoassay and Immunochemistry

Pivotal role of interleukin 27 serum level and missense variant (rs181206) in multiple sclerosis

Amany E. Elashkar M. E. Khalil Mona S. Elkholy Eman Samy Sanaa S. Hamam Amira Samy Elmaghraby

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Key Points

The study aims to examine the role of interleukin 27 and its genetic variations in the development of multiple sclerosis.
Assessment of interleukin 27 serum levels in relation to MS susceptibility.
Analysis of the missense variant (rs181206) in the context of genetic risk factors.
TT genotype and T allele increase the risk of developing multiple sclerosis.
C allele is associated with a lower risk of developing multiple sclerosis.

Implication

Research investigates interleukin 27 levels and genetic variants in multiple sclerosis, suggesting therapeutic potential.

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Cite This Study

Elashkar et al. (2026) studied this question.

synapsesocial.com/papers/6988270a0fc35cd7a8845e68 https://doi.org/10.1080/15321819.2026.2623279

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Search for informative predictors of the development and progression of multiple sclerosis2025
2An IL-5 Single-Nucleotide Polymorphism Influences Neuroinflammation and Prospective Disease Activity in Multiple Sclerosis2024 · 4 citations
3Impact of Genetic Polymorphisms in the Interleukin-18 and Interleukin-21 Genes on the Risk and Clinical Outcomes of Multiple Sclerosis2024 · 1 citations
4The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis2024 · 5 citations
5Differential Roles of IL-18 and IL-8 Gene Variations in Multiple Sclerosis: Associations with Susceptibility and MRI Disease ActivityOriginal Research · 2026

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