Impact of protein corona morphology on nanoparticle diffusion in biological fluids: insights from a mesoscale approach.

Beatrice Cipriani; Hender López

doi:10.1039/d5sm01152c

January 1, 2026Soft MatterOpen Access

Impact of protein corona morphology on nanoparticle diffusion in biological fluids: insights from a mesoscale approach.

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Key Points

This research aims to understand how the shape and structure of a protein corona around nanoparticles affect their movement in biological environments.
Conducted mesoscale simulations of nanoparticle diffusion in biological fluids
Analyzed protein corona morphology on nanoparticles
Examined the effect of different protein types on diffusion rates
Identified distinct diffusion patterns influenced by protein shape
Showed that certain protein coronas enhance nanoparticle movement
Found that diverse proteins can either hinder or facilitate diffusion

Implication

Mesoscale analysis highlights how protein interactions affect nanoparticle movement in biological fluids, suggesting improved drug delivery strategies.

Abstract

Nanoparticles (NPs) demonstrate considerable potential in medical applications, including targeted drug delivery and diagnostic probes. However, their efficacy depends on their ability to navigate through the complex biological environments inside...

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Cite This Study

Cipriani et al. (2026) studied this question.

synapsesocial.com/papers/698827670fc35cd7a8846305 https://doi.org/10.1039/d5sm01152c

View Full Paper

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Impact of protein corona morphology on nanoparticle diffusion in biological fluids: insights from a mesoscale approach.

Key Points

Implication

Abstract

Discussion

Cite This Study

Impact of protein corona morphology on nanoparticle diffusion in biological fluids: insights from a mesoscale approach.

Key Points

Implication

Abstract

Discussion

Cite This Study

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