Key result
Female Brugada syndrome patients face similar lethal arrhythmic risk as males despite lower VF inducibility.
Why the study?
Risk management of female patients with Brugada syndrome remains unclear, prompting investigation into whether their arrhythmic risk differs from male patients.
Does the arrhythmic risk of female Brugada syndrome patients differ from that of male patients?
Does the arrhythmic risk of female Brugada syndrome patients differ from that of male patients?
Female patients with Brugada syndrome present at an older age and have a higher prevalence of family history of sudden death or VF, but their long-term risk of lethal arrhythmic events is comparable to that of male patients.
Similar arrhythmic risk in female and male Brugada patients supports uniform monitoring; observational data leaves open sex-specific risk validation.
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Chishaki et al. (2025) studied this question. Female Brugada syndrome patients had similar long-term risk of lethal arrhythmic events as males (HR 0.60, P=0.22) despite lower VF inducibility and older age at diagnosis.
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