Key result
Pre-PFA imaging-based sizing enables safe combination of PFA and LAAO in LAA-origin atrial tachycardia.
Why the study?
Pulsed-field ablation may treat left atrial appendage-origin atrial tachycardia but can cause thrombus formation, which concomitant transcatheter LAA occlusion may mitigate.
Does concomitant pulsed-field ablation and transcatheter LAA occlusion provide effective sealing in patients with LAA-origin atrial tachycardia?
Case Report (n=1)
Does concomitant pulsed-field ablation and transcatheter LAA occlusion provide effective sealing in patients with LAA-origin atrial tachycardia?
Concomitant pulsed-field ablation and LAA occlusion is feasible for LAA-origin atrial tachycardia, but requires careful pre-PFA imaging-based device sizing due to PFA-induced tissue edema.
Urges caution on device sizing for combined PFA-LAAO; leaves open need for prospective validation in LAA-origin AT.
BACKGROUND: Pulsed-field ablation (PFA) may be an emerging treatment for left atrial appendage (LAA)-origin atrial tachycardia (AT), but it may cause thrombus in the LAA. Concomitant transcatheter LAA occlusion (LAAO) may address this risk. CASE SUMMARY: A 54-year-old man with symptomatic LAA-origin AT underwent PFA. Post-PFA transesophageal echocardiography showed significant pectinate muscle edema with narrowing of the LAA orifice. To avoid late peridevice leak, a 40-mm Watchman FLX Pro (Boston Scientific) was implanted with intentional overcompression. At the 1-month follow-up, cardiac computed tomography demonstrated a complete LAA seal with adequate device compression. DISCUSSION: Concomitant PFA and LAAO is feasible for LAA-origin AT. Because PFA can induce significant edema within the LAA, device selection based on pre-PFA imaging is critical to ensure durable sealing. TAKE-HOME MESSAGES: Careful pre-PFA imaging-based device sizing is critical when combining PFA with LAAO in patients with LAA-origin AT.
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Komatsu et al. (2026) conducted a case report in Left atrial appendage (LAA)-origin atrial tachycardia (AT) (n=1). Pulsed-field ablation with transcatheter LAA occlusion was evaluated on Complete LAA seal with adequate device compression. Concomitant pulsed-field ablation and transcatheter LAA occlusion achieved a complete LAA seal at 1-month follow-up in a 54-year-old man with LAA-origin atrial tachycardia.
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