Two-point multiparameter screening reduced prevalence of abnormalities from 34% at recruitment to 14.5% persistent abnormalities after follow-up in Nigerian schoolchildren.
Observational (n=228)
No
Two-point multiparameter screening in schoolchildren reveals a significant prevalence of persistent albuminuria and low eGFR, identifying a high-risk group that may benefit from early detection and intervention.
Absolute Event Rate: 14.5% vs 34%
p-value: p=<0.001
Background. Screening for persistent hypertension, albuminuria and low estimated glomerular filtration rate (eGFR) in children may allow for early detection of kidney disease, paving the way for early intervention to slow disease progression. Objective. To determine the prevalence of persistent hypertension, albuminuria and low eGFR and their associated factors in schoolchildren. Method. The study screened 228 schoolchildren (aged 5 - 15 years) from February 2020 to February 2021. Information about participants’ sociodemographic profile and medical history was obtained through questioning. Participants’ height, weight and blood pressure (BP) were measured. Their spot urine was assessed for albumin creatinine ratio (ACR), and blood for serum creatinine and eGFR. Participants with abnormal findings had a repeat assessment after a minimum of 3 months for BP, ACR and eGFR. Results. The median (range) age was 13.0 (11.1 - 14.0) years, with 117 males and 111 females. Seventy-eight of the children (34%) had at least one abnormality (hypertension 1.8%, albuminuria 28% and low eGFR 9%) at recruitment. At follow-up, 33 (42%) of the 78 children had persistent abnormal findings (hypertension 1.3%, albuminuria 10.1%, low eGFR 6%). Persistent albuminuria was seen more commonly in girls and in children with low eGFR. Older children (>10 years) were more likely to have low eGFR. Conclusion. A two-point, multiparameter screening of children may reveal high-risk groups for kidney disease that would require further evaluation and long-term follow-up. Such screenings can be integrated into school entry health assessment programmes to allow for early detection of kidney disease.
Mudi et al. (Wed,) conducted a observational in Schoolchildren aged 5-15 years in Kano metropolis, Nigeria without established hypertension or kidney disease (n=228). Two-point multiparameter screening for hypertension, albuminuria, and low eGFR vs. Initial screening vs follow-up screening after at least 3 months was evaluated on Prevalence of persistent hypertension, albuminuria, and low eGFR after follow-up (p=<0.001). Two-point multiparameter screening reduced prevalence of abnormalities from 34% at recruitment to 14.5% persistent abnormalities after follow-up in Nigerian schoolchildren.