What question did this study set out to answer?

The aim is to investigate how heparin affects the responses of endothelial cells to vascular endothelial growth factor.

Modulation of the effect of vascular endothelial growth factor on endothelial cells by heparin: Critical role of nitric oxide-mediated mechanisms

View Full Paper

Ask AI

Bookmark

Authors

Examines how heparin influences endothelial cell responses to vascular endothelial growth factor, indicating a protective role.

The aim is to investigate how heparin affects the responses of endothelial cells to vascular endothelial growth factor.
Bovine aorta endothelial cells were treated with high and low molecular weight heparin.
Measurements included 3H-thymidine uptake, flow cytometry, and cytosolic free calcium levels.
Nitrites accumulation, eNOS mRNA expression, and tissue factor concentration were also analyzed.
Both high and low molecular weight heparin blocked VEGF-induced proliferation and calcium transients.
Heparins did not interfere with the protective effects of VEGF on endothelial cells.
VEGF-related nitric oxide production increased in response to heparin treatment.
The Akt/PI3K pathway was implicated in mediating the effects of heparin on NO production.

Yagüe et al. (2005) studied this question.

View Full Paper

Ask AI

Bookmark