What does this research mean for the field?

The presence of brown adipose tissue (BAT) is independently associated with lower odds of cardiometabolic diseases, including type 2 diabetes and coronary artery disease, particularly in individuals with overweight or obesity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

January 1, 2021Nature MedicineOpen Access

Brown adipose tissue is associated with cardiometabolic health

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Why the study?

Although thermogenic adipose tissues improve glucose and lipid homeostasis in mice, the extent to which brown adipose tissue influences metabolic and cardiovascular disease in humans is unclear.

Does the presence of brown adipose tissue reduce the prevalence of cardiometabolic diseases in patients undergoing PET-CT?

Population

52,487 patients undergoing 134,529 18F-fluorodeoxyglucose PET-CT scans for cancer-related indications

Comparison

Presence vs absence of brown adipose tissue

Design

Retrospective propensity score-matched cohort study

Authors

TBTobias BecherHeidelberg University SPSrikanth PalanisamyJohns Hopkins Hospital DKDaniel J. KramerLovelace Respiratory Research Institute

Discussion

Member takes

Implication

BAT on PET-CT signals lower cardiometabolic risk in obesity; hypothesis-generating, should not yet change practice.

Structured PICO

Does the presence of brown adipose tissue reduce the prevalence of cardiometabolic diseases in patients undergoing PET-CT?

Population

52,487 patients (134,529 scans) undergoing 18F-fluorodeoxyglucose positron emission tomography-computed tomography scans for indications related to cancer diagnosis, treatment or surveillance, without previous stimulation

Intervention

Presence of brown adipose tissue (BAT)

Comparator

Absence of brown adipose tissue (BAT) (propensity score matched)

Outcome

Prevalence of cardiometabolic diseases (type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure and hypertension)

The presence of brown adipose tissue is associated with improved cardiometabolic health and lower odds of cardiovascular and metabolic diseases, especially in overweight or obese individuals.

Cite This Study

Becher et al. (2021) studied this question.

synapsesocial.com/papers/698b62fd2edb2383ed55317b https://doi.org/10.1038/s41591-020-1126-7

Topics

Lipid management Coronary artery disease Coronary CT angiography

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Brown adipose tissue is associated with cardiometabolic health

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Brown adipose tissue is associated with cardiometabolic health

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider