Key result
Provider education linked to ~76% relative increase in secondary prevention patients meeting LDL-C targets.
Why the study?
Does an educational intervention improve the achievement of LDL-C goals (<55 mg/dL) in patients with prior atherothrombotic events?
Observational (n=4,790)
Yes
Does an educational intervention improve the achievement of LDL-C goals (<55 mg/dL) in patients with prior atherothrombotic events?
Effect estimate: absolute increase 25.1%, relative increase 76.1%
Absolute Event Rate: 58.1% vs 33%
An educational intervention for cardiology centers significantly increased the proportion of secondary prevention patients achieving LDL-C <55 mg/dL, largely through increased use of low-cost therapies like statins and ezetimibe.
Structured Abstract Background and aims Adherence to guideline recommendations for secondary prevention appears to be inadequate, even in cardiology centers. To narrow the gap between guideline recommendations and what is implemented in clinical practice, we designed the BRING-UP Prevention project. Methods BRING-UP Prevention is a nationwide, observational, prospective, multicenter study enrolling patients with a prior atherothrombotic event. The study consists of two 3-month enrolment phases followed by a 6-month follow-up, with each phase preceded by an educational intervention. Data presented here mainly focus on the percentage of patients at goal for LDL-cholesterol (LDL-C) (<55 mg/dL) at the 6-month follow-up in the recently completed first enrollment phase. Secondary endpoints are blood pressure, glycemic and weight control and smoke cessation. Results Over 3 months, 189 cardiology centres recruited 4790 patients. Follow-up data at 6 months were available for 4643 patients (97%) and LDL-C was available for 4334 of them. The rate of patients with LDL-C <55 mg/dL increased from 33% to 58.1%, with absolute and relative increases of 25.1% and 76.1%, respectively. At 6 months 94.9% of patients were prescribed on statins. Atorvastatin and rosuvastatin were the most prescribed statins, mostly at high doses. Ezetimibe was prescribed in 84% of cases. PCSK9i monoclonal antibodies and inclisiran were prescribed in 8.3% of patients. Conclusions BRING-UP Prevention achieved its primary goal to increase the percentage of patients at LDL-C goal, demonstrating that, in many patients, this goal can be achieved increasing the use of low-cost therapies.
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Colivicchi et al. (2026) conducted an observational in Prior atherothrombotic event (n=4,790). Educational intervention (BRING-UP Prevention project) vs. Baseline was evaluated on Percentage of patients at goal for LDL-cholesterol (LDL-C) (<55 mg/dL) (absolute increase 25.1%, relative increase 76.1%). An educational intervention in cardiology centers increased the percentage of patients with a prior atherothrombotic event achieving LDL-C <55 mg/dL from 33% to 58.1% at 6 months.
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