Key result
Cardiac resynchronization therapy significantly decreased left ventricular end-systolic and end-diastolic volumes after 3 months (p < 0.001), correlating inversely with QRS recovery (r = 0.65).
Why the study?
To assess the relationship between left ventricular remodeling evaluated by strain echocardiography and conventional echocardiography before and after CRT in patients with severe heart failure.
Does cardiac resynchronization therapy improve left ventricular remodeling assessed by strain and conventional echocardiography in severe heart failure patients?
Cross-Sectional (n=33)
No
Does cardiac resynchronization therapy improve left ventricular remodeling assessed by strain and conventional echocardiography in severe heart failure patients?
p-value: p=<0.001
Cardiac resynchronization therapy significantly improves left ventricular volume and ejection fraction at 3 months, with strain echocardiography serving as a useful tool for monitoring remodeling.
May support strain echocardiography for post-CRT remodeling assessment in severe HF; extends observational data but leaves open randomized confirmation.
Background/Aims: To assess the relationship between left ventricular remodeling as evaluated by strain echocardiography and conventional echocardiography before and after cardiac resynchronization therapy (CRT) in patients with severe heart failure patients. Methods: A cross-sectional descriptive study with follow-up comparison before and after. The study was conducted on 33 heart failure patients indicated for CRT at the Vietnam National Heart Institute, Bach Mai Hospital from late 2015 to December 2021. Results: The study showed some correlations and changes in left ventricular remodeling assessed by strain echocardiography and conventional echocardiography before and after CRT. Left ventricular end-systolic volume and end-diastolic volume significantly decreased after 3 months of follow-up (p < 0.001) and had a strong inverse correlation with QRS recovery in study patients (r = 0.65). A positive correlation was observed between changes in left atrial volume index (LAVI) and 4B strain (r = 0.96, p < 0.05). After 3 months of CRT implantation, there was a positive correlation between the isovolumic relaxation time (IVRT) and left atrial volume (LAVI) (p < 0.05) and between the left atrial volume and E/e' obtained from tissue Doppler (r = 0.53, p < 0.05). However, there was no correlation observed between E/e' and total EF (r = -0.36, p > 0.05), between 2B strain and total EF (r = -0.36, p > 0.05) and between 2B strain and left atrial volume LAVI (r = 0.36, p > 0.05). Conclusion: Strain echocardiography is an important tool that cannot be overlooked in diagnosing, assessing risk factors, and monitoring heart failure. After 3 months of CRT implantation, there was significant improvement in left ventricular volume and ejection fraction (EF). This indicates better treatment effectiveness.
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Tran et al. (2026) conducted a cross-sectional in Severe heart failure (n=33). Cardiac resynchronization therapy (CRT) vs. Baseline (before CRT) was evaluated on Left ventricular end-systolic volume and end-diastolic volume (p=<0.001). Cardiac resynchronization therapy significantly decreased left ventricular end-systolic and end-diastolic volumes after 3 months (p < 0.001), correlating inversely with QRS recovery (r = 0.65).
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