What question did this study set out to answer?

To review current imaging technologies and approaches for assessing intestinal epithelial barrier integrity and related alterations.

February 14, 2026AJP Gastrointestinal and Liver Physiology

Tools and Advanced Imaging Technologies for Assessing Intestinal Epithelial Barrier Integrity: A Systematic Review

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To review current imaging technologies and approaches for assessing intestinal epithelial barrier integrity and related alterations.
Conducted a systematic review of in vivo and ex vivo/in vitro assessment techniques.
Evaluated non-invasive approaches including urinary detection of probes and their limitations.
Examined advanced invasive techniques like confocal laser endomicroscopy and transepithelial electrical resistance.
Highlighted emerging technologies such as impedance spectroscopy and organic electrochemical transistors.
Identified gaps in standardization and specificity of current diagnostic tools.
Noted advanced endoscopic modalities provide real-time visualization but are not widely available.
Found that in vitro methods remain the reference standard despite novel technologies showing promise.

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Implication

This systematic review evaluates imaging technologies to assess barrier integrity in the intestinal epithelium, suggesting implications for disease management.

Cite This Study

Vieujean et al. (2026) studied this question.

synapsesocial.com/papers/699011932ccff479cfe584e3 https://doi.org/10.1152/ajpgi.00447.2025

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Implication

This systematic review evaluates imaging technologies to assess barrier integrity in the intestinal epithelium, suggesting implications for disease management.

Tools and Advanced Imaging Technologies for Assessing Intestinal Epithelial Barrier Integrity: A Systematic Review

Key Points

Discussion

Implication

Cite This Study

Tools and Advanced Imaging Technologies for Assessing Intestinal Epithelial Barrier Integrity: A Systematic Review

Key Points

Discussion

Implication

Cite This Study

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