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February 19, 2026Open Access

Tools and Advanced Imaging Technologies for Assessing Intestinal Epithelial Barrier Integrity: A Systematic Review.

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This review aims to summarize the methods for assessing intestinal epithelial barrier integrity and identify gaps in current techniques.
Reviewed current in vivo (non-invasive and invasive) and ex vivo/in vitro techniques for assessing epithelial barrier alterations.
Evaluated urinary probes, circulating markers, fecal markers, and endoscopic modalities like confocal laser endomicroscopy.
Discussed in vitro methods, focusing on transepithelial electrical resistance and novel technologies.
Identified limitations in non-invasive methods, particularly regarding standardization and specificity.
Noted that advanced endoscopic techniques provide good visualization but are costly and primarily research-oriented.
Highlighted gaps including a lack of standardized definitions, practical diagnostic tools, and unvalidated thresholds.

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Systematic review evaluates technologies for assessing intestinal barrier integrity, indicating gaps in standardization and validation.

Vieujean et al. (2026) studied this question.

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