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September 10, 2007Archives of Internal Medicine

Association of Overweight With Increased Risk of Coronary Heart Disease Partly Independent of Blood Pressure and Cholesterol LevelsA Meta-analysis of 21 Cohort Studies Including More Than 300 000 Persons

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Why the study?

Does overweight increase the risk of coronary heart disease independent of blood pressure and cholesterol levels?

Population

Persons included in 21 cohort studies

Design

Meta-analysis

Authors

RBRik BogersMaastricht School of Management

Discussion

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Implication

Overweight confers independent CHD risk beyond BP and cholesterol; supports broader prevention strategies targeting weight.

Key Points

  • Determine the proportion of excess coronary heart disease risk associated with overweight that is mediated by blood pressure and cholesterol levels versus independent pathways.
  • Conducted a meta-analysis pooling data from 21 prospective cohort studies comprising more than 300,000 individuals.
  • Evaluated the association between overweight and coronary heart disease endpoints after adjusting for traditional risk factors, including blood pressure and serum cholesterol.
  • Adverse effects of overweight on blood pressure and cholesterol levels accounted for approximately 45% of the increased risk of coronary heart disease.
  • Moderate overweight remained significantly associated with elevated coronary heart disease risk independently of blood pressure and cholesterol levels.

Structured PICO

Does overweight increase the risk of coronary heart disease independent of blood pressure and cholesterol levels?

P
Population
Persons included in 21 cohort studies
I
Intervention
Overweight
O
Outcome
Coronary Heart Disease (CHD)hard clinical

Overweight significantly increases the risk of coronary heart disease, and this risk is only partly mediated by its adverse effects on blood pressure and cholesterol.

Limitations

  • Confounding (eg, by dietary factors) cannot be completely ruled out

Cite This Study

Rik Bogers (2007) studied this question.

synapsesocial.com/papers/6991ff751c7ab1ded6fb2f7chttps://doi.org/10.1001/archinte.167.16.1720
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