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February 16, 2026The Journal of PhysiologyOpen Access

Dynamic balance of myoplasmic energetics, redox state and protons in a fast‐twitch oxidative glycolytic skeletal muscle fibre

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Authors

JDJana DischUniversity of StuttgartJJJeroen A.L JenesonUniversity Medical Center UtrechtDBDaniel A. BeardLaboratoire d’immunologie intégrative du cancer

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Implication

Modeling shows redox state influenced by Lactate dehydrogenase in skeletal muscle fibres, suggesting crucial metabolic roles.

Key Points

  • This research aims to explore the mechanisms regulating energy and redox balance in skeletal muscle.
  • Developed a computational model of glycolysis and oxidative phosphorylation in muscle fibres.
  • Identified the model against in vivo recordings of phosphocreatine, inorganic phosphate, and pH.
  • Conducted step response testing and LDH knockout simulations for analysis.
  • Feedback control maintains myoplasmic ATP homeostasis across a wide ATP turnover range.
  • Predicts second-order underdamped behavior in the ATP metabolic network.
  • Indicates Lactate dehydrogenase's role is critical to redox balance, surpassing its function in acidification.

Cite This Study

Disch et al. (2026) studied this question.

synapsesocial.com/papers/699264d1eb1f82dc367a09afhttps://doi.org/10.1113/jp289702
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Also Consider

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  1. 1Regulation of mammalian muscle type 6‐phosphofructo‐1‐kinase and its implication for the control of the metabolism2010 · 137 citations
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  4. 4Metabolism of rat brain mitochondria. Studies on the potassium ion-stimulated oxidation of pyruvate1971 · 44 citations
  5. 5Oxygen cost of twitch and tetanic isometric contractions of rat skeletal muscle1986 · 71 citations