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Demonstrates a CRISPR/Cas9 probe detecting EGFR L858R mutation in CTCs, suggesting improved cancer diagnostics.
A CRISPR/Cas9-regulated dual-ring topological allosteric probe was developed for ultrasensitive and specific detection of the EGFR L858R mutation, where the released reporter ring triggers RCA and fluorescent probe hybridization for signal readout.
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Wang et al. (2026) studied this question.
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