A case-control study demonstrates altered brain connectivity linked to depression in psoriasis patients, suggesting implications for treatment.
The findings reveal a "dual-circuit" dysfunction pattern in psoriatic depression: sgACC-DMN hyperconnectivity linked to depressive symptoms, and sgACC-dlPFC (dorsolateral prefrontal cortex) alterations associated with IL-17 elevation. These results establish the sgACC as a neural hub bridging inflammation and mood dysregulation, supporting the "skin-brain axis" hypothesis. The identified FC patterns may serve as biomarkers for targeted interventions in inflammation-related depression.
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Liu et al. (2026) studied this question.
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