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January 1, 2026Organic Chemistry FrontiersOpen Access

Amine-cation-driven heteroannulation of halomaleimides with C–N cleavage: metal-free access to heterobicyclic frameworks

Luka Ciber Luka Ciber Nejc Petek Jurij Svete Uroš Grošelj Bogdan Štefane

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Key Points

The aim is to achieve a mild and efficient method for synthesizing heterobicyclic frameworks.
Utilized halomaleimides and quaternary enamines in the synthesis process.
Focused on metal-free reaction conditions.
Achieved synthesis in synthetically useful yields.
Successfully synthesized 3,4-diamin-substituted maleimide heterobicycles.
Yielded significant amounts of the desired heterobicyclic compounds.

Implication

Mild synthesis demonstrates efficient heteroannulation in heterobicyclic frameworks, implying improved synthetic strategies.

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Cite This Study

Ciber et al. (2026) studied this question.

synapsesocial.com/papers/6996a8a9ecb39a600b3ef993 https://doi.org/10.1039/d6qo00010j

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