Cobalt-Catalyzed C−H Annulation of Aliphatic Amides with Maleimides: Chemodivergent (4+1) and (3+2) Pathways

Celia Sánchez; Juan C. Carretero; Inés Alberdi Alonso; Nuria Rodriguez; Javier Adrio

doi:10.1039/d6qo00080k

January 1, 2026Organic Chemistry FrontiersOpen Access

Cobalt-Catalyzed C−H Annulation of Aliphatic Amides with Maleimides: Chemodivergent (4+1) and (3+2) Pathways

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Key Points

This research aims to explore the chemodivergent C−H annulation of aliphatic amides with maleimides using cobalt catalysis.
Utilized cobalt(II) catalyst for reactions
Performed C−H annulation of aliphatic amides with maleimides
Generated (4+1) and (3+2) outcome pathways
Successfully achieved (4+1) and (3+2) chemodivergent outcomes
Demonstrated efficiency of the cobalt catalyst
Highlighted the accessibility of the reaction conditions

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Implication

Chemodivergent C−H annulation produces distinct outcomes in aliphatic amides, suggesting versatile synthetic applications.

Abstract

Chemodivergent C−H annulation of aliphatic amides with maleimides has been achieved under cobalt-catalysis, enabling access to distinct (4+1) and (3+2) outcomes. These protocols, utilizing a readily available CoII catalyst, deliver...

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Sánchez et al. (2026) studied this question.

synapsesocial.com/papers/69994c5d873532290d020cb9 https://doi.org/10.1039/d6qo00080k

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Cobalt-Catalyzed C−H Annulation of Aliphatic Amides with Maleimides: Chemodivergent (4+1) and (3+2) Pathways

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cobalt-Catalyzed C−H Annulation of Aliphatic Amides with Maleimides: Chemodivergent (4+1) and (3+2) Pathways

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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