Why the study?
Although the sympathetic nervous system contributes to elevated blood pressure, the determinants of persistent sympathetic overactivity remain incompletely understood.
Recent basic research expands the understanding of sympathetic regulation in hypertension, highlighting the brain and kidneys as key sources of sympathetic overactivity and identifying novel therapeutic targets.
Variable renal denervation response warrants sympathetic phenotyping before use; leaves open optimal patient selection and targets.
The sympathetic nervous system plays a pivotal role in the pathophysiology of hypertension. Although the contribution of the sympathetic nervous system to an elevation of blood pressure is well established, the determinants of persistent sympathetic overactivity remain incompletely understood. This review summarizes the findings of recent basic research that have expanded the understanding of sympathetic regulation in hypertension, highlighting emerging mechanisms and providing insights into the development of novel therapeutic strategies.
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Naoyoshi Sakitani (2026) conducted a review in Patients with hypertension and sympathetic nervous system overactivity. Renal denervation vs. Pharmacological or no intervention was evaluated on Blood pressure reduction.
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