Renal denervation shows variable efficacy for blood pressure reduction across patient cohorts with hypertension involving sympathetic nervous system overactivity.
Abstract The sympathetic nervous system plays a pivotal role in the pathophysiology of hypertension. Although the contribution of the sympathetic nervous system to an elevation of blood pressure is well established, the determinants of persistent sympathetic overactivity remain incompletely understood. This review summarizes the findings of recent basic research that have expanded the understanding of sympathetic regulation in hypertension, highlighting emerging mechanisms and providing insights into the development of novel therapeutic strategies.
Naoyoshi Sakitani (2026) conducted a review in Patients with hypertension and sympathetic nervous system overactivity. Renal denervation vs. Pharmacological or no intervention was evaluated on Blood pressure reduction. Renal denervation shows variable efficacy for blood pressure reduction across patient cohorts with hypertension involving sympathetic nervous system overactivity.