What question did this study set out to answer?

To examine the pathophysiological role of sympathetic nervous system alterations in human hypertension, evaluate clinical diagnostic assessment techniques, and review therapeutic sympathetic deactivation interventions.

March 12, 2015Circulation Research

The Sympathetic Nervous System Alterations in Human Hypertension

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To examine the pathophysiological role of sympathetic nervous system alterations in human hypertension, evaluate clinical diagnostic assessment techniques, and review therapeutic sympathetic deactivation interventions.
Assessed methodologies for quantifying sympathetic nerve activity in humans, including heart rate monitoring, plasma norepinephrine assays, microneurography, and radiolabeled norepinephrine spillover measurements.
Synthesized mechanistic and clinical evidence on neuroadrenergic hyperactivity across essential hypertension and secondary forms related to obesity and renal disease.
Evaluated device-based therapeutic sympathetic deactivation strategies, specifically carotid baroreceptor stimulation and renal nerve radiofrequency ablation.
Neuroadrenergic hyperactivity serves as a primary driver and amplifier in the onset and maintenance of elevated blood pressure in humans.
Sympathetic nerve overactivation is prominently involved in the pathophysiology of secondary hypertension associated with obesity and chronic renal disease.
Neuromodulatory interventions targeting sympathetic deactivation, including catheter-based renal denervation and carotid baroreceptor stimulation, provide effective therapeutic modalities for blood pressure reduction.

Structured PICO

Population

Humans with hypertension, including secondary forms associated with obesity and renal disease

Intervention

Sympathetic deactivation therapies, specifically carotid baroreceptor stimulation and radiofrequency ablation of the renal nerves

The review outlines the pathophysiological role of the sympathetic nervous system in hypertension and discusses the rationale for device-based sympathetic deactivation therapies.

Discussion

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Implication

Supports investigation of device-based sympathetic deactivation in hypertension; leaves open efficacy and safety pending randomized trials.

Cite This Study

Grassı et al. (2015) studied this question.

synapsesocial.com/papers/69d77ebaef4aa71f97f317b7 https://doi.org/10.1161/circresaha.116.303604

Topics

Hypertension management

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Implication

Supports investigation of device-based sympathetic deactivation in hypertension; leaves open efficacy and safety pending randomized trials.

The Sympathetic Nervous System Alterations in Human Hypertension

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

The Sympathetic Nervous System Alterations in Human Hypertension

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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