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February 19, 2026BJA OpenOpen Access

Procalcitonin and interleukin-6 to diagnose infection in cardiac surgery patients with hyperinflammation: a two-centre, prospective cross-sectional study

Ted Reniers Noordzij Pg Eline Harding Henk J.T. Ruven Maaike S Y Thio Marloes Langelaan Ineke M. Dijkstra Lisette M. Vernooij Olaf Cremer Thijs C.D. Rettig

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Key Points

Evaluate the diagnostic performance of procalcitonin and interleukin-6 in cardiac surgery patients with suspected early infection.
Conducted a two-centre, prospective cross-sectional study.
Included elective cardiac surgery patients with suspected infection based on clinical criteria.
Assessed diagnostic thresholds for procalcitonin and interleukin-6 using likelihood ratios.
Infection confirmed in 21 out of 284 patients (7%).
Procalcitonin showed an area under the curve (AUC) of 0.59, insufficient for clinical use.
Interleukin-6 demonstrated a better AUC of 0.70, indicating potential for ruling out infection.

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Implication

This prospective study examines infection diagnosis in cardiac surgery patients, indicating IL-6's potential.

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Cite This Study

Reniers et al. (2026) studied this question.

synapsesocial.com/papers/699a9ca1482488d673cd2705 https://doi.org/10.1016/j.bjao.2026.100538

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