What question did this study set out to answer?

To characterize the novel HLA-DQA1*05:65:01:01 allele and understand its genetic differences.

February 22, 2026HLA

Characterisation of the Novel HLA‐DQA1*05:65:01:01 Allele by Next‐Generation Sequencing

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This research characterises the HLA-DQA1*05:65:01:01 allele, uncovering genetic differences, implying its relevance in genetic studies.

To characterize the novel HLA-DQA1*05:65:01:01 allele and understand its genetic differences.
Used next-generation sequencing to analyse the HLA-DQA1 gene.
Identified nucleotide substitutions in the allele.
Focused on codon 218 in exon 4 for genetic differences.
HLA-DQA1*05:65:01:01 differs from HLA-DQA1*05:05:01:02 by one nucleotide substitution.
The specific substitution was identified at codon 218 in exon 4.

Chiali et al. (2026) studied this question.

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