Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA
Why the study?
Does a combination of clopidogrel and aspirin reduce major ischemic events in patients with minor ischemic stroke or high-risk TIA?
Population
patients with minor ischemic stroke or high-risk TIA
Comparison
combination of clopidogrel and aspirin vs aspirin alone
Design
RCT
Follow-up
90 days
Authors
Discussion
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Implication
Supports short-term dual antiplatelet therapy in minor stroke or high-risk TIA; confirms ischemic benefit with bleeding trade-off from prior RCTs.
Key Points
- To evaluate the safety and effectiveness of clopidogrel combined with aspirin in patients with minor ischemic stroke or high-risk TIA.
- Randomized trial comparing clopidogrel and aspirin versus aspirin alone
- Evaluated major ischemic events and hemorrhage risks at 90 days
- Trial registration ID NCT00991029
- Combination therapy reduced major ischemic events compared to aspirin alone
- Increased risk of major hemorrhage at 90 days with combination therapy
- Exact rates of ischemic events and hemorrhages not provided.
Structured PICO
Does a combination of clopidogrel and aspirin reduce major ischemic events in patients with minor ischemic stroke or high-risk TIA?
P
Population
patients with minor ischemic stroke or high-risk TIA
I
Intervention
combination of clopidogrel and aspirin
C
Comparator
aspirin alone
O
Outcome
major ischemic events at 90 dayshard clinical
In patients with minor ischemic stroke or high-risk TIA, dual antiplatelet therapy with clopidogrel and aspirin reduces major ischemic events but increases major hemorrhage at 90 days compared to aspirin alone.
Cite This Study
Johnston et al. (2018) studied this question.