Why the study?
Does combined clopidogrel-aspirin therapy initiated within 72 hours after stroke onset reduce the risk of new stroke at 90 days in patients with mild ischemic stroke or high-risk TIA of presumed atherosclerotic cause?
Does combined clopidogrel-aspirin therapy initiated within 72 hours after stroke onset reduce the risk of new stroke at 90 days in patients with mild ischemic stroke or high-risk TIA of presumed atherosclerotic cause?
Initiating combined clopidogrel-aspirin therapy within 72 hours of a mild ischemic stroke or high-risk TIA reduces the risk of new stroke at 90 days compared to aspirin alone, though with a slight increase in bleeding risk.
Supports early dual antiplatelet therapy in mild stroke or high-risk TIA; confirms benefit of clopidogrel-aspirin initiated within 72 hours.
Among patients with mild ischemic stroke or high-risk TIA of presumed atherosclerotic cause, combined clopidogrel-aspirin therapy initiated within 72 hours after stroke onset led to a lower risk of new stroke at 90 days than aspirin therapy alone but was associated with a low but higher risk of moderate-to-severe bleeding. (Funded by the National Natural Science Foundation of China and others; INSPIRES ClinicalTrials.gov number, NCT03635749.).
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Gao et al. (2023) studied this question.
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