Why the study?
Does the combination of clopidogrel and aspirin reduce the risk of stroke in patients with TIA or minor stroke who can be treated within 24 hours after the onset of symptoms?
Population
Patients with TIA or minor stroke who can be treated within 24 hours after the onset of symptoms
Comparison
Combination of clopidogrel and aspirin vs Aspirin alone
Design
RCT
Follow-up
90 days
Authors
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Supports dual antiplatelet therapy within 24 hours after TIA or minor stroke; confirms superiority over aspirin alone without excess hemorrhage in this RCT.
Does the combination of clopidogrel and aspirin reduce the risk of stroke in patients with TIA or minor stroke who can be treated within 24 hours after the onset of symptoms?
In patients with acute minor stroke or TIA, dual antiplatelet therapy with clopidogrel and aspirin initiated within 24 hours reduces 90-day stroke risk without increasing hemorrhage compared to aspirin alone.
Wang et al. (2013) studied this question.
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