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February 24, 2026Open Access

Genomic Characterization of Salmonella Isolates Causing Infections in Children with Sickle Cell Disease in Dakar, Senegal

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Authors

ADAmadou DiopADArfang DiamankaAGAdja Bousso Guèye

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Overview

Characterizes Salmonella isolates in children with sickle cell disease, suggesting need for increased surveillance.

Key Points

  • This research aims to characterize the Salmonella isolates responsible for infections in children with sickle cell disease in Senegal.
  • Conducted antimicrobial susceptibility testing on Salmonella isolates.
  • Utilized whole-genome sequencing for detailed genetic analysis.
  • Performed bioinformatic analysis to assess virulence factors and serovar diversity.
  • Investigated 23 isolates from children with diverse clinical infections.
  • Identified 12 different serovars of Salmonella with Enteritidis as the most common.
  • Twenty-two isolates showed full susceptibility to antibiotics, while one exhibited multidrug resistance.
  • Eight isolates carried a virulence plasmid with the spvRABCD gene cluster.
  • Core pathogenicity islands were found in all isolates, indicating a potential for invasiveness.

Cite This Study

Diop et al. (2026) studied this question.

synapsesocial.com/papers/699d3fb3de8e28729cf64675https://doi.org/10.3390/microorganisms14020506
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Also Consider

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