Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 8, 2026Journal of sickle cell disease.Open Access

Whole-Genome Analysis of Salmonella Associated with Osteomyelitis in Senegalese Children with Sickle Cell Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

ENEl Hadji Aly NiangADAmadou DiopAGAdja Bousso Guèye

Discussion

Loading...

Member takes

Overview

Whole-genome analysis reveals Salmonella serovars linked to osteomyelitis in children with sickle cell disease, suggesting a need for better surveillance.

Key Points

  • To analyze Salmonella isolates from osteomyelitis cases in children with sickle cell disease in Senegal.
  • Confirmed Salmonella isolates using MALDI-TOF biotyping.
  • Performed antimicrobial susceptibility testing via disc diffusion method.
  • Executed whole-genome sequencing on an Illumina platform.
  • Conducted bioinformatic analyses with open-access tools.
  • Isolates identified belonged to seven serovars, predominantly Enteritidis and Typhimurium.
  • 11 isolates were fully susceptible to tested antibiotics, while one was extensively drug-resistant.
  • Most isolates carried significant virulence factors, including Salmonella Pathogenicity Islands.

Cite This Study

Niang et al. (2026) studied this question.

synapsesocial.com/papers/6988278b0fc35cd7a8846579https://doi.org/10.1093/jscdis/yoag008
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genomic Characterization of Salmonella Isolates Causing Infections in Children with Sickle Cell Disease in Dakar, Senegal2026
  2. 2Osteomyelitis in Sickle Cell Anemia: Does Age Predict Risk of Salmonella Infection?2023 · 12 citations
  3. 3SICKLE CELL DISEASE AND OSTEOMYELITIS CAUSED BY SALMONELLA SP IN A PEDIATRIC PATIENT – CASE REPORT2026
  4. 4Salmonella bloodstream infection and concurrent intestinal colonization in children with severe acute malnutrition in Niger2026
  5. 5Bacterial isolates in febrile children with sickle cell disease using molecular methods in sub-Saharan African – a single center study2026