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February 24, 2026Journal of Functional Foods1 citationsOpen Access

Wild Rice-Derived Exosome-Like Nanoparticles Relieve Insulin Resistance in HepG2 Cells

Wild Rice-derived exosome-like nanoparticles relieve insulin resistance in HepG2 cells

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Authors

HZH. ZhangHZH. ZhangFWFeng Wang

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Overview

In vitro study investigates the effects of wild rice-derived nanoparticles on insulin resistance in HepG2 cells, suggesting potential therapeutic implications.

Key Points

  • This study aims to explore the effects of wild rice-derived exosome-like nanoparticles on insulin resistance and their mechanisms in HepG2 cells.
  • Prepared exosome-like nanoparticles from Chinese wild rice using differential centrifugation.
  • Established an insulin resistance model in HepG2 cells.
  • Analyzed the modulation of oxidative stress and glucose metabolism pathways.
  • WRNPs enhanced SOD, CAT, and GSH levels, reducing MDA levels and oxidative stress in IR-HepG2 cells.
  • WRNPs improved glucose uptake by promoting glycolysis and inhibiting gluconeogenesis.
  • Modulation of the KEAP1/Nrf2/HO-1 and IRS-1/PI3K/AKT signaling pathways was observed.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/699d4028de8e28729cf653achttps://doi.org/10.1016/j.jff.2026.107189
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Also Consider

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  3. 3Local Rice Consumption and the Risk of Developing Insulin Resistance in Wistar Albino Rats2024
  4. 4Hypoglycemic Activity of Rice Resistant-Starch Metabolites: A Mechanistic Network Pharmacology and In Vitro Approach2024 · 7 citations
  5. 5Brown Yar Ko Rice Protects Against Hyperglycemia‐Induced Endothelial Injury via Antioxidant and SIRT1 Activation2026