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February 25, 2026Nicotine & Tobacco Research2 citationsOpen Access

The role of the orbitofrontal cortex in smoking cue-reactivity in onset phase of smoking behaviour, a fMRI study in adolescents

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DTD R M TesselaarASA F A SchellekensJHJ R Homberg

Key Points

  • Examine the role of the orbitofrontal cortex (OFC) in smoking cue-reactivity among adolescents.
  • Used fMRI to measure brain activity in response to smoking cues.
  • Compared regular smoking adolescents to non-smokers.
  • Focused on regions of interest (ROI) analyses primarily in the left OFC.
  • Found increased activity in the left OFC in regular smoking adolescents compared to non-smokers.
  • Implicated OFC reactivity as an early marker for tobacco use disorder (TUD).

Abstract

Overall, we only observed increased smoking cue-related brain activity in the left OFC in regular smoking adolescents compared to non-smokers in the ROI analyses. These results suggest that OFC reactivity to smoking cues could be one of the first signs of the development of TUD.

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Cite This Study

Tesselaar et al. (2026) studied this question.

synapsesocial.com/papers/699e9177f5123be5ed04efd4https://doi.org/10.1093/ntr/ntag045
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