Meta-analysis identifies genetic markers associated with weight gain in adults with severe mental illness, suggesting risk assessment strategies.
The study identified six SNPs that predispose adult individuals to AIWG, with HTR2C rs3813929 and ADRA2A rs1800544 showing the largest effect sizes. Five of these have a role in hypothalamic regulation of appetite/satiety. Identification of these risk-associated SNPs may assist the development of a polygene/polyphenotypic risk score to identify individuals with psychosis who are at heightened risk of experiencing AIWG.
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Warner‐Levy et al. (2026) studied this question.
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