What question did this study set out to answer?

This case aims to explore the transmission of Neisseria meningitidis from mother to neonate at birth.

February 26, 2026Communicable Diseases Intelligence0 citationsOpen Access

Maternal vaginal colonisation with Neisseria meningitidis serogroup B and late onset neonatal invasive meningococcal disease

NBNadiya BrellWollongong Hospital CSChloe StoryWollongong Hospital SHSebastiaan Van HalRoyal Prince Alfred Hospital

Key Points

This case aims to explore the transmission of Neisseria meningitidis from mother to neonate at birth.
Maternal vaginal swab taken at delivery
Neonatal cerebrospinal fluid culture performed
Whole genome sequencing of isolates conducted
Neonatal meningococcal disease diagnosed late onset
Both maternal and neonatal samples positive for Neisseria meningitidis
Identical strains detected with only one SNP difference

Abstract

Here we report a case of late onset neonatal invasive meningococcal disease that was vertically transmitted, with maternal vaginal swab at the time of delivery and neonatal cerebrospinal fluid culture positive for Neisseria meningitidis. Whole genome sequencing of meningococcal isolates in the neonatal cerebrospinal fluid and maternal vaginal found both Men-B ST-2506 (clonal complex 32) and identical (1 SNP difference on split kmer analysis).

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