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February 26, 2026Singapore Medical JournalOpen Access

Neurological diseases linked to diverse ECG changes that reflect neurocardiac injury and inform management.

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Population

3 patients presenting with neurological conditions and ECG changes

Design

Case series

Key result

Neurological diseases cause diverse ECG changes like cerebral T-wave inversions, QT prolongation, and new arrhythmias; these reflect neurocardiac injury and inform management.

Authors

FGFang Qin GohMLMervyn Jun Rui LimCNChin Hong Ngai

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Overview

Prompts differentiation of neurocardiac from ischaemic ECG changes in neurological emergencies; leaves open prognostic role and management impact pending prospective study.

Key Points

  • This paper investigates the ECG findings in patients with neurological conditions and their clinical implications.
  • Three case series of patients with neurological symptoms and ECG analysis were presented.
  • Electrocardiograms from patients were compared over time to identify changes.
  • Clinical outcomes and cardiac evaluations such as echocardiography and imaging were conducted.
  • ECG changes included T-wave inversions and QT prolongation in a patient with intracranial lesions.
  • Atrial fibrillation was noted in a patient following a cerebellar hemorrhage, which reverted spontaneously.
  • Sinus bradycardia was observed in a patient with a thalamic hematoma, resolving later during the hospitalization.

Structured PICO

P
Population
3 elderly patients (ages 74, 85, 86) presenting with acute neurological conditions (post-radiotherapy cerebral edema, cerebellar hematoma, thalamic hematoma) and associated ECG abnormalities.
O
Outcome
Electrocardiogram (ECG) abnormalities at presentation and during admissionsurrogate

Neurological emergencies can manifest with profound ECG changes and arrhythmias via the neurocardiac axis, which must be differentiated from primary cardiac ischemia.

Cite This Study

Goh et al. (2026) studied this question. Neurological diseases cause diverse ECG changes like cerebral T-wave inversions, QT prolongation, and new arrhythmias; these reflect neurocardiac injury and inform management.

synapsesocial.com/papers/699fe3f995ddcd3a253e8106https://doi.org/10.4103/singaporemedj.smj-2024-168
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Also Consider

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  1. 1Electrocardiogram Changes in Intracranial Space Occupying Lesion2019
  2. 2Cause of ST-segment elevation on electrocardiogram2022 · 1 citations
  3. 3Mechanism of Stress-Induced Cardiomyopathy Complicated with Acute Cerebral Infarction2026
  4. 4Cerebral T Waves in Aneurysmal Subarachnoid Hemorrhage: An Uncommon ECG Manifestation Mimicking Myocardial Ischaemia–A Case Report2025
  5. 5Myocardial ischemic changes of electrocardiogram in intracerebral hemorrhage: A case report and review of literature2019 · 10 citations