Digitalis in the pre-excitation syndrome. Analysis during atrial fibrillation.
Why the study?
Does digitalis affect the ventricular response during atrial fibrillation in patients with Wolff-Parkinson-White syndrome?
Population
Patients with Wolff-Parkinson-White (WPW) syndrome
Comparison
Digitalis vs Control data (baseline/pre-digitalis state)
Design
Case_series
Authors
Discussion
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Member takes
Implication
Digitalis may precipitate VF in WPW-AF; leaves open its net effect on ventricular response and requires prospective study.
Structured PICO
Does digitalis affect the ventricular response during atrial fibrillation in patients with Wolff-Parkinson-White syndrome?
P
Population
Patients with Wolff-Parkinson-White (WPW) syndrome
I
Intervention
Digitalis
C
Comparator
Control data (baseline/pre-digitalis state)
O
Outcome
Ventricular response during atrial fibrillation (shortest R-R cycle length) and antegrade/retrograde refractory periods of accessory pathwayssurrogate
Digitalis has unpredictable effects on antegrade conduction in WPW syndrome and can precipitate life-threatening ventricular fibrillation, particularly in patients with a short baseline R-R interval during atrial fibrillation.
Cite This Study
Sellers et al. (1977) studied this question.