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February 27, 2026Shengming kexueOpen Access

Research progress on amino acid metabolic reprogramming in hepatocellular carcinoma

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This review explores metabolic reprogramming in HCC, revealing therapeutic strategies and implications for treatment.

The aim is to summarize the mechanisms of amino acid metabolic reprogramming in hepatocellular carcinoma and its therapeutic implications.
Systematic review of molecular mechanisms associated with amino acid metabolism in HCC.
Analysis of metabolic pathways involving glutamine, branched-chain amino acids, arginine, serine, glycine, and tryptophan.
Review of current therapeutic strategies targeting metabolic enzymes and immune modulation.
Glutamine is crucial for HCC cell survival and proliferation, driving tumor progression.
Metabolic abnormalities in HCC involve altered amino acid uptake and signaling pathways like mTORC1.
Potential therapeutic strategies include inhibitors of metabolic enzymes and immunotherapies targeting amino acid pathways.

LI et al. (2026) studied this question.

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