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Study reveals CD72 downregulation in DN2 B cells associates with disease activity in systemic lupus erythematosus, suggesting a role in treatment resistance.
DN2 have been associated with autoimmunity. We show that DN2 in SLE have reduced CD72 expression which associates with anti-dsDNA positivity, complement consumption and enhanced BCR downstream signalling. The relative resistance of CD72-negative B cells to RTX indicates that impaired checkpoint programme in lupus B cells may potentially contribute to disease relapse. These findings require validation in larger cohorts.
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Wangriatisak et al. (2026) studied this question.
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