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The research aims to characterize the anti-breast cancer activity of red ginseng polysaccharide RGP-45, involving its extraction and purification.

February 28, 2026Results in ChemistryOpen Access

Characterization and study on the anti-breast cancer activity of polysaccharides from red ginseng

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Research characterizes red ginseng polysaccharide RGP-45 and its anti-breast cancer effects, highlighting its therapeutic potential.

The research aims to characterize the anti-breast cancer activity of red ginseng polysaccharide RGP-45, involving its extraction and purification.
Extracted polysaccharides from red ginseng were purified and named RGP-45.
Characterization included determining yield, molecular weight, and sugar composition.
In vitro tests assessed effects on 4T1 cell proliferation and apoptosis.
In vivo tests evaluated RGP-45's impact on tumor growth in breast cancer mice models.
RGP-45 yielded 12.59% with a relative molecular weight of 27.8 kDa and total sugar content of 91.57%.
RGP-45 significantly inhibited 4T1 cell proliferation and promoted apoptosis.
In vivo, RGP-45 treatment inhibited tumor growth in mice.
RGP-45 treatment alleviated liver and lung damage in mice bearing tumors.

Li et al. (2026) studied this question.

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