Why the study?
Beneficial effects of P2Y12 receptor antagonists may extend beyond preventing arterial thrombosis, given that platelet activation and nonplatelet P2Y12 receptors play roles in inflammation.
Do P2Y12 receptor antagonists have beneficial anti-inflammatory effects beyond their antithrombotic role?
Design
Review
Authors
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P2Y12 inhibition may confer anti-inflammatory benefits across sepsis, lung injury, and atherosclerosis; leaves open confirmation in prospective trials.
Do P2Y12 receptor antagonists have beneficial anti-inflammatory effects beyond their antithrombotic role?
P2Y12 receptor antagonists may offer therapeutic benefits beyond thrombosis by modulating inflammation in various diseases.
Mansour et al. (2020) studied this question.
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