Why the study?
How does left ventricular diastolic functional reserve during exercise relate to ventricular elastance and exercise capacity in patients with impaired myocardial relaxation at rest?
How does left ventricular diastolic functional reserve during exercise relate to ventricular elastance and exercise capacity in patients with impaired myocardial relaxation at rest?
In patients with abnormal resting LV relaxation, lower diastolic functional reserve during exercise correlates with higher ventricular elastance and reduced exercise capacity.
May identify diastolic reserve as contributor to exercise intolerance in impaired relaxation; hypothesis-generating, needs prospective confirmation.
Despite similar mitral flow and annular velocities at rest, different responses to exercise were seen in patients with abnormal LV relaxation at rest. Lower LV diastolic functional reserve was associated with higher ventricular elastance during exercise, and reduced exercise capacity.
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Ha et al. (2008) studied this question.
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