Age- and Gender-Related Ventricular-Vascular Stiffening
Why the study?
Are advancing age and female gender associated with increased ventricular-vascular stiffening in the general community?
Population
2,042 residents of Olmsted County, Minn, aged ≥45 years, including a subset of 623 individuals without known…
Design
Cross-sectional
Authors
Discussion
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Overview
May explain higher HFpEF prevalence in elderly women; hypothesis-generating for causal mechanisms and interventions.
Key Points
- This study aims to investigate the relationship between age, gender, and ventricular-vascular stiffness in the general community.
- Cross-sectional study conducted in Olmsted County with 2042 residents aged 45 and older.
- Clinical data, Doppler echocardiography, and blood pressure measurements were collected.
- Elastance measures (Ea, Ees, Ed) were calculated and compared by age and gender.
- Elastance measures EaI, Ees, and Ed significantly increased with age in both genders (P<0.0001).
- Ees increased more steeply with age in women compared to men (P=0.002).
- Even in absence of cardiovascular disease, women had higher elastance values than men after adjusting for age (P<0.0001).
Structured PICO
Are advancing age and female gender associated with increased ventricular-vascular stiffening in the general community?
P
Population
2,042 residents of Olmsted County, Minn, aged ≥45 years, including a subset of 623 individuals without known or suspected cardiovascular disease.
O
Outcome
Vascular elastance indexed to body size (EaI), ventricular systolic elastance (Ees), and operant ventricular diastolic elastance (Ed)surrogate
Advancing age and female sex are associated with increased ventricular and vascular stiffness, providing a potential mechanistic explanation for the higher prevalence of heart failure with preserved ejection fraction (HFpEF) in elderly women.
Cite This Study
Redfield et al. (2005) studied this question.