January 1, 2017Circulation JournalOpen Access

Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure　― New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients ―

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Population

479 hypertensive patients with preserved ejection fraction and no history of heart failure.

Design

Cohort

Authors

SHShiro HoshidaYao Tokushukai General Hospital YSYukinori ShinodaYao Tokushukai General Hospital KIKuniyasu IkeokaOsaka National Hospital

Discussion

Member takes

Implication

May warrant closer HFpEF monitoring in elderly hypertensive women; leaves open whether arterial elasticity is a modifiable target.

Structured PICO

Population

479 hypertensive patients with preserved ejection fraction (LVEF ≥50%) and no history of heart failure (267 men, 212 women).

Outcome

Age- and sex-related differences in diastolic function relative to arterial elasticity (EdI/EaI = E/e'/(0.9×SBP)).surrogate

Elderly women with hypertension exhibit highly fluctuating impairment of diastolic function relative to arterial elasticity, providing a potential mechanistic explanation for their predisposition to HFpEF.

Limitations

Retrospective database study
Lack of invasive hemodynamic data
Exclusion of patients with coronary artery disease and atrial fibrillation may underestimate indices

Cite This Study

Hoshida et al. (2017) studied this question.

synapsesocial.com/papers/6a73eba7cd7b40c8110dd9dc https://doi.org/10.1253/circj.cj-16-1126

Topics

HFrEF treatment Heart failure Hypertension management HFpEF management

View Full Paper

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Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure　― New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients ―

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure　― New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients ―

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider

Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure ― New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients ―

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure ― New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients ―

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider

Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure　― New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients ―

Fluctuation of Dynamic Diastolic Function Relative to Static Cardiac Structure　― New Insights Into the Underlying Mechanism of Heart Failure With Preserved Ejection Fraction in Elderly Patients ―