Key result
The ratio of left ventricular diastolic elastance to arterial elastance (Ed/Ea) is proposed as a novel index with diagnostic potential for HFpEF and a prognostic role in HFrEF.
Why the study?
Does the ratio of left ventricular diastolic elastance to arterial elastance (Ed/Ea) have diagnostic and prognostic value in heart failure?
Does the ratio of left ventricular diastolic elastance to arterial elastance (Ed/Ea) have diagnostic and prognostic value in heart failure?
The Ed/Ea ratio is highlighted as a novel index with potential diagnostic and prognostic utility in both HFpEF and HFrEF.
Heart failure (HF) with preserved ejection fraction (HFpEF) is thought to be driven by increased cardiac afterload, which consequentially leads to left ventricular (LV) diastolic dysfunction. The ratio of LV diastolic elastance (Ed) to arterial elastance (Ea) significantly increases in older hypertensive women without HF and is coincident with cardiac structural alterations. Ed/Ea is reported to be a prognostic factor for all-cause mortality in patients admitted with HFpEF. In this short article, I provide a possible view of this novel index as having diagnostic potential for HFpEF in clinics and playing a prognostic role in HF with reduced ejection fraction (HFrEF).
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Shiro Hoshida (2023) conducted a review in Heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Ratio of LV diastolic elastance (Ed) to arterial elastance (Ea) was evaluated on All-cause mortality. The ratio of left ventricular diastolic elastance to arterial elastance (Ed/Ea) is proposed as a novel index with diagnostic potential for HFpEF and a prognostic role in HFrEF.
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