Key result
A high vascular resistance-integrated diastolic index (Ed/Ea) significantly predicted all-cause mortality in women (HR 3.582) and heart failure readmission in men (HR 2.108) during the first year after discharge in patients with HFpEF.
Why the study?
None of the existing non-invasive diastolic indices consider arterial load.
Does a vascular resistance-integrated diastolic index (Ed/Ea) provide accurate prognostic evaluation in patients with HFpEF?
Observational (n=898)
Yes
Does a vascular resistance-integrated diastolic index (Ed/Ea) provide accurate prognostic evaluation in patients with HFpEF?
A novel echocardiographic index integrating vascular resistance and diastolic function (Ed/Ea) is proposed to improve prognostic accuracy in HFpEF patients.
None of the existing non-invasive diastolic indices consider arterial load. This article proposed the validity of a novel index of vascular resistance-integrated diastolic function, a ratio of left ventricular diastolic elastance (Ed) to arterial elastance (Ea), Ed/Ea = (E/e´)/(0.9 × systolic blood pressure), and its utility in the prognostic evaluation of patients with heart failure with preserved ejection fraction (HFpEF). Prognostic factors related to left atrial overload such as Ed/Ea may differ according to the clinical endpoint, follow-up duration and sex. In HFpEF patients with heterogenous cardiac structure and function, assessment using a serial echocardiographic vascular resistance-integrated diastolic index in clinical care can provide an accurate prognosis.
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Shiro Hoshida (2023) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=898). Vascular resistance-integrated diastolic index (Ed/Ea) vs. Low Ed/Ea was evaluated on All-cause mortality during the first year after discharge in women (HR 3.582, 95% CI 1.540-8.335, p=0.003). A high vascular resistance-integrated diastolic index (Ed/Ea) significantly predicted all-cause mortality in women (HR 3.582) and heart failure readmission in men (HR 2.108) during the first year after discharge in patients with HFpEF.
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