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Assess the potential of urinary amino acid concentrations to differentiate prostate cancer from benign cases and identify high-risk disease.

March 1, 2026In VivoOpen Access

Urinary Amino Acid Profiling as a Non-invasive Diagnostic and Risk Stratification Tool in Prostate Cancer

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Evaluates urinary amino acid profiling for diagnosing prostate cancer, suggesting improved accuracy and reduced biopsies.

Assess the potential of urinary amino acid concentrations to differentiate prostate cancer from benign cases and identify high-risk disease.
Collected first-morning urine samples from 90 men, including 60 with prostate cancer and 30 healthy controls.
Quantified total urinary amino acids using high-performance liquid chromatography with fluorescence detection.
Compared amino acid concentrations between prostate cancer patients and controls, with secondary analyses involving various clinical parameters.
Significant alterations in amino acids like glutamate+glutamine, arginine, leucine, and methionine were observed.
Leucine exhibited high discriminatory performance with an AUC of 0.79.
Combining PSA with selective amino acids improved diagnostic accuracy significantly.
Serine levels were lower in node-positive patients while histidine levels were elevated in high-risk cases.

Zdobinská et al. (2026) studied this question.

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