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February 27, 2026Cell ReportsOpen Access

Lipocalin 2 orchestrates resistance to ferroptosis via AXL

Sabrina Wang J. Payton Timken Ellen S. Hong Sehaj Kaur Eli Newby Kristen Kay Erin E. Mulkearns-Hubert Daniel J. Silver Juyeun Lee Joshua B. Rubin James R. Connor Loic P. Deleyrolle Deanna Tiek Andrew Dhawan Justin D. Lathia

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Key Points

The study aims to understand how lipocalin 2 contributes to resistance against ferroptosis through the modulation of AXL.
Investigated the role of lipocalin 2 in cellular models of ferroptosis
Analyzed AXL expression and activity in response to lipocalin 2 levels
Employed biochemical assays to assess ferroptosis resistance
Lipocalin 2 enhances resistance to ferroptosis in various cell lines
Increased AXL expression correlates with higher ferroptosis resistance
Inhibition of AXL reduced lipocalin 2's protective effect against ferroptosis

Implication

Research reveals how lipocalin 2 influences ferroptosis resistance via AXL, suggesting therapeutic targets.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a528ecf1e85e5c73bf063b https://doi.org/10.1016/j.celrep.2026.116965

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