Examines lactate to pyruvate AUC ratio alterations in a metabolic model, suggesting implications for metabolic understanding.
Changes observed in the AUC ratio may be driven by changes in pyruvate extravasation, transport into the cell, and/or intracellular metabolism. The proposed model permits parametric representation of the AUC ratio, identification of rate-limiting steps in lactate production, and correction for differences induced by acquisition parameters.
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Boyce et al. (2026) studied this question.
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