Key result
Epinephrine stimulation significantly decreased tracer-measured fractional extraction of lactate to -25.3% compared to 16.6% in controls, indicating transpulmonary lactate production.
Population
Anesthetized rat model
Comparison
Lactate load and epinephrine stimulation with… vs Control condition
Design
Preclinical
Authors
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Pulmonary AV lactate gradients may miss parenchymal production during epinephrine; leaves open accurate assessment of lung lactate metabolism.
Absolute Event Rate: -25.3% vs 16.6%
p-value: p=<0.05
Pulmonary arterial-vein concentration difference measurements across the lungs provide an incomplete picture of parenchymal lactate metabolism, particularly during epinephrine stimulation.
Johnson et al. (2011) studied Healthy (animal model) (n=21). Epinephrine stimulation and Lactate clamp vs. Control (tracer 90 µg/kg/min) was evaluated on Tracer-measured fractional extraction of lactate (FEXTM) during epinephrine stimulation (p=<0.05). Epinephrine stimulation significantly decreased tracer-measured fractional extraction of lactate to -25.3% compared to 16.6% in controls, indicating transpulmonary lactate production.
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